| 11:30 PM | Friends - The One With the Rumor: Monica encounters a high-school friend (Brad Pitt) and invites him to Thanksgiving Day dinner. |
| 12:00 AM | Friends - The One With Phoebe's Cookies: Chandler tries to bond with Monica's father during a racquetball session. |
| 12:30 AM | According to Jim - No Nookie: Cheryl convinces Jim to abstain from sex until their romantic getaway. |
| 1:00 AM | Family Guy - Road to Rhode Island: Stewie misbehaves while visiting his grandparents. |
| 1:30 AM | South Park - Clubhouses: The boys build rival clubhouses; Stan invites Wendy to play truth or dare. |
| 2:00 AM | Scrubs - My Conventional Wisdom: J.D. runs into an ex-girlfriend at a surgeons convention. |
| 2:30 AM | George Lopez - It's a Cliffhanger, by George: Benny flees when the police want to question her about an old robbery. |
| 3:00 AM | Star Trek: The Next Generation - The Nth Degree: An alien probe endows Barclay (Dwight Schultz) with superhuman intelligence. |
| 4:00 AM | Frasier - Morning Becomes Entertainment: Frasier's agent books him as a temporary host for a television talk show. |
| 4:30 AM | Local Programming |
| 9:00 AM | Maury: Joey Greco brings videos of unfaithful people; Gloria Allred brings stories of predators. |
| 10:00 AM | Maury: Mothers want men who deny being fathers to take paternity tests. |
| 11:00 AM | Jerry Springer: A woman hopes to get her mother to accept her lesbian lover by celebrating Thanksgiving with her. |
| 12:00 PM | The Steve Wilkos Show: A 13-year-old runaway says her mother's boyfriend repeatedly abused her and even tried to rape her. |
| 1:00 PM | Street Court: Judge Mazz holds court across America at the scenes of disputes. |
| 1:30 PM | Street Court: Judge Mazz holds court across America at the scenes of disputes. |
| 2:00 PM | Judge Mathis: A man sues his former friend for the cost of a puppy and defamation. |
| 3:00 PM | The Tyra Show: Tyra poses as a man; musician Chingy. |
| 4:00 PM | The Tyra Show: Authors Heidi Montag and Spencer Pratt discuss their new book, ``How to Be Famous.'' |
| 5:00 PM | Are You Smarter Than a 5th Grader? |
| 5:30 PM | Are You Smarter Than a 5th Grader? |
| 6:00 PM | Inside Edition: Home auctions. |
| 6:30 PM | Local Programming |
| 7:00 PM | Two and a Half Men - Baseball Was Better With Steroids: Charlie begins to question his relationship with Chelsea. |
| 7:30 PM | Family Guy - Brian Does Hollywood: Brian's first job in Hollywood is directing a pornographic film. |
| 8:00 PM | Gracie: A teenage girl fights to take her late brother's place on the boys soccer team. |
| 10:00 PM | Local Programming |
| 11:00 PM | Two and a Half Men - A Pot-Smoking Monkey: After their split, Alan wants to gain custody of his and Kandi's dog. |
| 11:30 PM | Friends - The One With Rachel's Other Sister: Rachel has a bone to pick with her self-centered sister (Christina Applegate) on Thanksgiving. |